Anti-CD38 in Transfusion Medicine

Anti-CD38 in Transfusion Medicine

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Marissa Laureano1,3, Akash Gupta2,3, Celina Montemayor3, Yulia Lin2

  1. Department of Medicine, McMaster University, Hamilton, ON, Canada
  2. Precision Diagnostics and Therapeutics Program, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
  3. Canadian Blood Services, Toronto, ON, Canada


As the end of this self-assessment module, participants should be able to:

  1. Describe how treatments with anti-CD38 monoclonal antibodies interfere with blood bank testing.
  2. Describe mitigation strategies to negate anti-CD38 interference with blood bank compatibility tests.
  3. Describe what tests should be ordered prior to initiating a patient on treatment with an anti-CD38 monoclonal antibody.

CHS Scientific Planning Committee Members (2021-22)

Dr. Joanne Britto – Resident Physician, Hematology-Oncology
Dr. Yan Xu – Fellow Physician, Hematology
Dr. Siraj Mithoowani – Clinical Hematologist at St. Joseph’s Healthcare, Hamilton
Dr. Hassan Sibai – Assistant Professor of Medicine, Faculty of Medicine, University of Toronto and Staff Physician, Division of Medical Hematology & Oncology, Princess Margaret Cancer Centre

Conflicts of Interest: None